What kind of antibody causes neonatal alloimmune thrombocytopenia?
a. Maternal antibody against a fetal platelet antigen inherited from the father
b. Fetal antibody directed against maternal platelet antigen
c. Fetal antibody against a fetal platelet antigen inherited from the father
d. Maternal autoantibody against a mother's platelet antigen
ANS: A
Neonatal alloimmune thrombocytopenia develops when a mother, during pregnancy, develops an alloantibody against a platelet antigen inherited by the fetus from the father. These antibodies cross the placenta, bind to the antigen-bearing fetal platelets, and cause their premature destruction.
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