Describe the typical experimental setup and procedure that would be used to produce long-term potentiation (LTP) and explain how this would be assessed using this procedure

What will be an ideal response?

Answer: A stimulating electrode would be inserted into the axons of the perforant path and a recording electrode inserted into the dentate gyrus. A population EPSP is recorded from the dentate cells to a single electrical pulse of the path. A burst of high-frequency stimulation is given and followed periodically by a single pulse. LTP is indicated by an increase in the size of the subsequent EPSPs following the burst treatment.