Compare and contrast the collection of umbilical cord stem cells for transplantation and that of allogeneic stem cells for transplantation
What will be an ideal response?
Answer: Umbilical cord stem cell transplantation.
Umbilical cord stem cells
Are abundantly available.
Specimen collection poses no risk to mother and infant.
Can be frozen
Have a low risk of viral contamination
Dos not have mature T cells, so risk of GVH is low
Generally have a low total number of stem cells for an adult transplant patient
Can reduce the GVL effect
Have only one unit available for each procedure
Allogeneic stem cells:
Are adequate for transplant in adults
Provide multiple units available for each procedure
Compatibility testing essential
Cryopreservation possible
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