Which of the following statements regarding ipratropium bromide are true? 1. It is a first-line choice of bronchodilator for chronic obstructive pulmonary disease (COPD). 2. It can be combined with a ??agonist for maintenance bronchodilation in COPD

3. It is added to a ? agonist in severe asthma episodes that do not respond to a ??agonist alone.
4. It is a leukotriene modifier used to treat step 3 asthma.

a. 1 and 4 only
b. 2 and 4 only
c. 1, 2, and 4 only
d. 1, 2, and 3 only

ANS: D