What is the most effective treatment for PA?
a. Oral folate
b. Injections of vitamin B12
c. Oral vitamin B12
d. Alterations in diet
ANS: B
PA is a deficiency of vitamin B12 (not folate) because of a lack of IF, which is required for absorption. The vitamin is usually administered by injection through muscle. Because IF deficiency is the actual defect, taking vitamin B12 orally will be of no benefit because it cannot be absorbed. Administering it by injection bypasses the need for absorption.
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