Explain the JAK-STAT signaling pathway, and describe how it can contribute to disease
What will be an ideal response?
Answer: JAK: Janus family PTKs (protein tyrosine kinases) interact with the STAT transcription factors (signal transducers and activators of transcription). Once STAT proteins are phosphorylated by activated JAK kinases, they dimerize, translocate to the nucleus, bind to cytokine-specific DNA sequences, and activate (or inhibit) specific gene expression. Abnormalities in this pathway have been shown to cause polycythemia vera and other myeloproliferative disorders.
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The base of the lung can be found where?
A) The base of the neck B) At the top of the sternum C) The level of the heart D) On top of the diaphragm
Which of the following actions represents the best course of action for a 13s quality-control failure?
A) Release all patient results and do not rerun control material that failed. B) Release all patient results but rerun the control material that failed. C) Do not release patient results, recalibrate the assay, and then rerun all levels of control material.