Which of the following causes a shift to the right on the oxygen dissociation curve?
a. Severe anemia
b. Alkalosis
c. High levels of Hb F
d. Decreased levels of 2,3-biphosphoglycerate (2,3-BPG)
ANS: A
Severe anemia causes a right shift of the oxygen dissociation curve. This means that the affinity of hemoglobin for oxygen is less, so more oxygen will be released to tissue (more effective delivery of oxygen). Alkalosis (increased pH), Hb F, and decreased levels of 2,3-BPG all shift the curve to the left.
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