Assume that 30 mg of drug A puts 10% of people to sleep and that 100 mg of drug A puts 80% of people to sleep. Assume that drug B has no effect on sleep at any dose (except at lethal doses)
If we give 100 mg of drug B along with 30 mg of drug A, we observe that the combination puts 50% of people to sleep. What phenomenon are we observing? Explain your answer.
What will be an ideal response?
Since drug B has no effect on sleep by itself and the 30 mg dose of drug A when combined with the dose of drug B produces effects greater than the effects induced by 30 mg of drug A alone, this would indicate that we are observing potentiation, a form of synergism.
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