All of the following would be expected 1 year after a splenectomy on a patient with severe hereditary spherocytosis except:
a. Spherocytes on the blood film
b. Howell-Jolly bodies
c. Reticulocyte count of 10%
d. Siderocytes
ANS: C
After splenectomy, the anemia is usually corrected and reticulocyte counts return to high normal. However, the consequences of splenectomy, done for whatever reason, are the appearance of Howell-Jolly bodies, siderocytes, and target cells in red cells. Spherocytes will still be observable in hereditary spherocytosis.
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