What condition is most associated with autosplenectomy?
a. Abdominal trauma
b. Thrombocytopenia
c. Sickle cell anemia
d. Iron deficiency
ANS: C
In sickle cell anemia, repeated sickling events in the spleen, where the red cells are stressed, result in multiple splenic infarcts. Eventually, the spleen is no longer functional. This results in functional loss of the spleen and is called an autosplenectomy.
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