You are treating a patient who suffers from renal disease and decreased perfusion of the kidneys. What effect will this have on the distribution of a drug that normally acts on kidneys, such as the diuretic medication Lasix?
a. The drug will be present in increased concentrations at the kidneys resulting in toxicity.
b. The drug will be poorly delivered to the kidneys due to a decreased perfusion and will not produce the desired results.
c. As the kidneys are a primary organ of elimination, the effects of the drug will be unchanged.
d. The drug will most likely be metabolized by the liver resulting in the same effects systemically..
b
Rationale: a. Decreased renal blood flow results in poor delivery of the medication to the kidney.
b. Correct.
c. The decreased blood flow to the kidney will prevent the drug from producing the desired results.
d. If a drug is meant for a specific organ of tissue, it must reach the site in order to be effective.
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