Which of the following results in ineffective thrombopoiesis?
a. Immune thrombocytopenic purpura
b. Thrombotic thrombocytopenic purpura
c. Disseminated intravascular coagulation (DIC)
d. Megaloblastic anemia
ANS: D
Thrombocytopenia because of ineffective thrombopoiesis is one of the usual features of megaloblastic anemias. Vitamin B12 and folic acid are both required for normal maturation of megakaryocytes in the bone marrow.
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