What is the role of the thrombin-thrombomodulin complex?
a. Initiates vasoconstriction
b. Activates thrombin
c. Inhibits factor Xa
d. Activates protein C
ANS: D
Thrombin binds the endothelial cell membrane protein thrombomodulin, and the complex then activates protein C. Activated protein C complexes with protein S, and the complex degrades factors Va and VIIIa, which downregulates thrombin generation.
Health Professions
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