The disorders that cause respiratory failure due to increased work of breathing include which of the following? 1. Myasthenia gravis 2. Cardiogenic pulmonary edema 3. Interstitial pulmonary fibrosis 4. Amyotrophic lateral sclerosis

a. 1 and 2 only
b. 2 and 3 only
c. 3 and 4 only
d. 1 and 4 only

ANS: B
Myasthenia gravis and amyotrophic lateral sclerosis are two neuromuscular disorders that cause respiratory failure through muscle weakness and paralysis. Both cardiogenic pulmonary edema and interstitial pulmonary fibrosis cause respiratory failure through increased work of breathing.