Which of the following can distinguish immune hemolytic anemia from hereditary spherocytosis in a patient with spherocytes?
a. Osmotic fragility
b. Reticulocyte count
c. Presence of polychromasia
d. Direct antiglobulin test
ANS: D
The immune hemolytic anemias with spherocytes are differentiated from hereditary spherocytosis by the presence of a positive direct antiglobulin test. This test, when positive, demonstrates the presence of antibodies on the red cell membrane.
Health Professions
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