Alkalization of urine by giving bicarbonate is used to treat patients presenting with phenobarbital (weak acid) overdose. Which of the following best describes the rationale for alkalization of urine in this setting?

A. To reduce tubular reabsorption of phenobarbital.
B. To decrease ionization of phenobarbital.
C. To increase glomerular filtration of phenobarbital.
D. To decrease proximal tubular secretion.
E. To increase tubular reabsorption of phenobarbital.

Answer: A. To reduce tubular reabsorption of phenobarbital.