Describe three mechanisms that might explain why an alcohol-dependent individual might have to take more of the drug to experience the same effects

What will be an ideal response?

The three mechanisms are 1) drug disposition tolerance - use of a drug that increases a drug's rate of metabolism or excretion, therefore requiring a greater dose to obtain the same result; 2) behavioral tolerance - individuals learn to adapt to the altered state and compensate for the impairment; and 3) pharmacodynamic tolerance - sensitivity of neurons to a drug changes in an attempt by the brain to maintain its level of functioning within normal limits.