Which of the following clinical manifestations are associated with the more negative intrapleural pressures needed during inspiration?

1. Thick, tenacious secretions
2. Intercostal retractions
3. Nasal flaring
4. Mediastinal shift
a. 1, 3
b. 2, 3
c. 2, 3, 4
d. 1, 2, 3, 4

B
Clinical manifestations associated with the more negative intrapleural pressures needed during inspiration include, but are not limited to, intercostal retractions and nasal flaring.