Which of the following physical examination findings could be considered a late manifestation of interstitial lung disease (ILD)?

a. Bronchial wheezing
b. Increased wedge pressure
c. Peripheral cyanosis
d. Pulmonary hypertension

ANS: D
Signs of pulmonary arterial hypertension with right ventricular dysfunction, such as lower ex-tremity edema or jugular venous distention, may occur late in the course of any ILD and are not helpful in the diagnosis of a specific ILD.