What is the role cofactors play in the procoagulant process?
a. Bind fibrinolytic factors to slow down lysis of the clot
b. Bind Ca2+ to form a bridge with platelet phospholipids
c. Bind to their specific activated serine protease to stabilize the protease and increase its activity
d. Bind to collagen to aid in platelet adhesion
ANS: C
Cofactors bind to their specific activated serine protease to stabilize the protease and increase its activity. One example is the binding of the cofactor Va to factor Xa, which then magnifies the activity of factor Xa to activate prothrombin.
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