Tartrate-resistant acid phosphatase is strongly positive in which of the following cells?
a. Myeloblasts
b. Hairy cells
c. Granulocytes
d. Lymphocytes
ANS: B
Hairy cells are positive for acid phosphatase when tartrate is added to the incubation mixture. They uniquely contain an abundance of acid phosphatase isoenzyme 5; all other isoenzymes of acid phosphatase, found in almost all other blood cells, are inhibited in the presence of tartrate. At least two or more cells should contain >40 red granules to call the stain positive.
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