Which of the following, using Wright stain, is a feature of normal cells as they mature?
a. Overall size increases
b. Nucleoli become more prominent
c. Nuclear chromatin becomes more condensed
d. Cytoplasmic basophilia increases
ANS: C
Nuclear chromatin is initially diffuse or dispersed; as a cell matures, the chromatin undergoes a process of condensing and stains more intensely with Wright stain. The overall cell size decreases; nucleoli are no longer visible if even present, and cytoplasmic basophilia, present because of the high concentration of RNA in a young cell, decrease.
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